טוען...
Stapling of two PEGylated side chains increases the conformational stability of the WW domain via an entropic effect
Hydrocarbon stapling and PEGylation are distinct strategies for enhancing the conformational stability and/or pharmacokinetic properties of peptide and protein drugs. Here we combine these approaches by incorporating asparagine-linked O-allyl PEG oligomers at two positions within the β-sheet protein...
שמור ב:
| הוצא לאור ב: | Org Biomol Chem |
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| Main Authors: | , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2018
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6290918/ https://ncbi.nlm.nih.gov/pubmed/30444518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ob02535e |
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