Stapling of two PEGylated side chains increases the conformational stability of the WW domain via an entropic effect

Hydrocarbon stapling and PEGylation are distinct strategies for enhancing the conformational stability and/or pharmacokinetic properties of peptide and protein drugs. Here we combine these approaches by incorporating asparagine-linked O-allyl PEG oligomers at two positions within the β-sheet protein...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Org Biomol Chem
Asıl Yazarlar: Xiao, Qiang, Bécar, Natalie A., Brown, Nathaniel P., Smith, Mason S., Stern, Kimberlee L., Draper, Stven R. E., Thompson, Katherine P., Price, Joshua L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290918/
https://ncbi.nlm.nih.gov/pubmed/30444518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ob02535e
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