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PEGylation near a patch of non-polar surface residues increases the conformational stability of the WW domain
Many proteins have one or more surface-exposed patches of non-polar residues; our observations here suggest that PEGylation near such locations might be a useful strategy for increasing protein conformational stability. Specifically, we show that conjugating a PEG-azide to a propargyloxyphenylalanin...
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| Gepubliceerd in: | J Org Chem |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8147659/ https://ncbi.nlm.nih.gov/pubmed/31749365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b02615 |
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