Influence of PEGylation on the strength of protein surface salt bridges

Conjugation of polyethylene glycol (PEGylation) is a well-known strategy for extending the serum half-life of protein drugs and for increasing their resistance to proteolysis and aggregation. We previously showed that PEGylation can increase protein conformational stability; the extent of PEG-based...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:ACS Chem Biol
Autors principals: Xiao, Qiang, Draper, Steven R. E., Smith, Mason S., Brown, Nathan P., Pugmire, Natalie A. B., Ashton, Dallin S., Carter, Anthony J., Lawrence, Eliza E. K., Price, Joshua L.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8147658/
https://ncbi.nlm.nih.gov/pubmed/31188563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00432
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars