Influence of PEGylation on the strength of protein surface salt bridges

Conjugation of polyethylene glycol (PEGylation) is a well-known strategy for extending the serum half-life of protein drugs and for increasing their resistance to proteolysis and aggregation. We previously showed that PEGylation can increase protein conformational stability; the extent of PEG-based...

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Bibliographic Details
Published in:ACS Chem Biol
Main Authors: Xiao, Qiang, Draper, Steven R. E., Smith, Mason S., Brown, Nathan P., Pugmire, Natalie A. B., Ashton, Dallin S., Carter, Anthony J., Lawrence, Eliza E. K., Price, Joshua L.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8147658/
https://ncbi.nlm.nih.gov/pubmed/31188563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00432
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