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Influence of PEGylation on the strength of protein surface salt bridges
Conjugation of polyethylene glycol (PEGylation) is a well-known strategy for extending the serum half-life of protein drugs and for increasing their resistance to proteolysis and aggregation. We previously showed that PEGylation can increase protein conformational stability; the extent of PEG-based...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | ACS Chem Biol |
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| Κύριοι συγγραφείς: | , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8147658/ https://ncbi.nlm.nih.gov/pubmed/31188563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00432 |
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