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High throughput evaluation of macrocyclization strategies for conformer stabilization
While macrocyclization of a linear compound to stabilize a known bioactive conformation can be a useful strategy to increase binding potency, the difficulty of macrocycle synthesis can limit the throughput of such strategies. Thus computational techniques may offer the higher throughput required to...
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| Publicado no: | Sci Rep |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5920116/ https://ncbi.nlm.nih.gov/pubmed/29700331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24766-5 |
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