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Evaluation of an Orthogonal Pooling Strategy for Rapid High-Throughput Screening of Proteases

Orthogonal pooling was evaluated as a strategy for the rapid screening of multiple cysteine and serine proteases against large compound libraries. To validate the method the human cysteine protease cathepsin B was screened against a library of 64,000 individual compounds and also against the same li...

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מידע ביבליוגרפי
Main Authors: Motlekar, Nuzhat, Diamond, Scott L., Napper, Andrew D.
פורמט: Artigo
שפה:Inglês
יצא לאור: Mary Ann Liebert, Inc. 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2971631/
https://ncbi.nlm.nih.gov/pubmed/18593377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2007.110
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