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Evaluation of an Orthogonal Pooling Strategy for Rapid High-Throughput Screening of Proteases
Orthogonal pooling was evaluated as a strategy for the rapid screening of multiple cysteine and serine proteases against large compound libraries. To validate the method the human cysteine protease cathepsin B was screened against a library of 64,000 individual compounds and also against the same li...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Mary Ann Liebert, Inc.
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2971631/ https://ncbi.nlm.nih.gov/pubmed/18593377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2007.110 |
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