Effects of a Common Eight Base Pairs Duplication at the Exon 7-Intron 7 Junction on Splicing, Expression, and Function of OCT1

Organic cation transporter 1 (OCT1, SLC22A1) is localized in the sinusoidal membrane of human hepatocytes and mediates hepatic uptake of weakly basic or cationic drugs and endogenous compounds. Common amino acid substitutions in OCT1 were associated with altered pharmacokinetics and efficacy of drug...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Römer, Sarah, Meyer, Marleen J., Klein, Kathrin, Schneider, Lennart V., Matthaei, Johannes, Tzvetkova, Ana, Łapczuk-Romańska, Joanna, Gaedcke, Jochen, Droździk, Marek, Brockmöller, Jürgen, Nies, Anne T., Tzvetkov, Mladen V.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137991/
https://ncbi.nlm.nih.gov/pubmed/34025422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.661480
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