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Isobutyrylcarnitine as a Biomarker of OCT1 Activity and Interspecies Differences in its Membrane Transport

Genome-wide association studies have identified an association between isobutyrylcarnitine (IBC) and organic cation transporter 1 (OCT1) genotypes. Higher IBC blood concentrations in humans with active OCT1 genotypes and experimental studies with mouse OCT1 suggested an OCT1-mediated efflux of IBC....

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Jensen, Ole, Matthaei, Johannes, Klemp, Henry G., Meyer, Marleen J., Brockmöller, Jürgen, Tzvetkov, Mladen V.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8141810/
https://ncbi.nlm.nih.gov/pubmed/34040533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.674559
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