Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment

Por Brockmöller, Jürgen, Tzvetkov, Mladen V.
Publicado em 2008

Benzydamine N-oxidation as an index reaction reflecting FMO activity in human liver microsomes and impact of FMO3 polymorphisms on enzyme activity

Por Störmer, Elke, Roots, Ivar, Brockmöller, Jürgen
Publicado em 2000

Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

Por Sachse, Christoph, Brockmöller, Jürgen, Bauer, Steffen, Roots, Ivar
Publicado em 1999

Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans

Por Kirchheiner, Julia, Meineke, Ingolf, Steinbach, Nadine, Meisel, Christian, Roots, Ivar, Brockmöller, Jürgen
Publicado em 2003

Protocol for MInimizing the Risk of Metachronous Adenomas of the CoLorectum with Green Tea Extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for...

Por Stingl, Julia C, Ettrich, Thomas, Muche, Rainer, Wiedom, Martina, Brockmöller, Jürgen, Seeringer, Angela, Seufferlein, Thomas
Publicado em 2011

Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin

Por Sükrü Aynacioglu, A, Brockmöller, Jürgen, Bauer, Steffen, Sachse, Christoph, Güzelbey, Pinar, Öngen, Zuhal, Nacak, Muradiye, Roots, Ivar
Publicado em 1999

Hepatocyte Nuclear Factor 1 Regulates the Expression of the Organic Cation Transporter 1 via Binding to an Evolutionary Conserved Region in Intron 1 of the OCT1 Gene

Por O’Brien, Valerie P., Bokelmann, Kristin, Ramírez, Jacqueline, Jobst, Karoline, Ratain, Mark J., Brockmöller, Jürgen, Tzvetkov, Mladen V.
Publicado em 2013

Torsemide renal clearance and genetic variation in luminal and basolateral organic anion transporters

Por Vormfelde, Stefan V, Schirmer, Markus, Hagos, Yohannes, Toliat, Mohammad R, Engelhardt, Sabine, Meineke, Ingolf, Burckhardt, Gerhard, Nürnberg, Peter, Brockmöller, Jürgen
Publicado em 2006

CYP2D6 Genotyping as an alternative to phenotyping for determination of metabolic status in a clinical trial setting

Por McElroy, Suzin, Richmond, Jodi, Lira, Maruja, Friedman, David, Silber, B. Michael, Milos, Patrice M., Sachse, Christoph, Brockmöller, Jürgen, Roots, Ivar
Publicado em 2000

Impact of UGT2B7 (His268Tyr )polymorphism on the outcome of adjuvant epirubicin treatment in breast cancer

Por Parmar, Sumit, Stingl, Julia Carolin, Huber-Wechselberger, Ariana, Kainz, Alexander, Renner, Wilfried, Langsenlehner, Uwe, Krippl, Peter, Brockmöller, Jürgen, Haschke-Becher, Elisabeth
Publicado em 2011

Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1

Por Seitz, Tina, Stalmann, Robert, Dalila, Nawar, Chen, Jiayin, Pojar, Sherin, Dos Santos Pereira, Joao N., Krätzner, Ralph, Brockmöller, Jürgen, Tzvetkov, Mladen V.
Publicado no Genome Med (2015)

Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other me...

Por Matthaei, Johannes, Tzvetkov, Mladen V., Gal, Valerie, Sachse-Seeboth, Cordula, Sehrt, Daniel, Hjelmborg, Jakob B., Hofmann, Ute, Schwab, Matthias, Kerb, Reinhold, Brockmöller, Jürgen
Publicado no Genome Med (2016)

CYP2D6 and CYP2C19 in Papua New Guinea: High frequency of previously uncharacterized CYP2D6 alleles and heterozygote excess

Por von Ahsen, Nicolas, Tzvetkov, Mladen, Karunajeewa, Harin A, Gomorrai, Servina, Ura, Alice, Brockmöller, Jürgen, Davis, Timothy M E, Mueller, Ivo, Ilett, Kenneth F, Oellerich, Michael
Publicado em 2010

The Poorly Membrane Permeable Antipsychotic Drugs Amisulpride and Sulpiride Are Substrates of the Organic Cation Transporters from the SLC22 Family

Por Dos Santos Pereira, Joao N., Tadjerpisheh, Sina, Abed, Manar Abu, Saadatmand, Ali R., Weksler, Babette, Romero, Ignacio A., Couraud, Pierre-Olivier, Brockmöller, Jürgen, Tzvetkov, Mladen V.
Publicado no AAPS J (2014)

Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among...

Por Seegers, Joachim, Vos, Marc A., Flevari, Panagiota, Willems, Rik, Sohns, Christian, Vollmann, Dirk, Lüthje, Lars, Kremastinos, Dimitrios T., Floré, Vincent, Meine, Mathias, Tuinenburg, Anton, Myles, Rachel C., Simon, Dirk, Brockmöller, Jürgen, Friede, Tim, Hasenfuß, Gerd, Lehnart, Stephan E., Zabel, Markus
Publicado em 2012

Relevance of Sp Binding Site Polymorphism in WWOX for Treatment Outcome in Pancreatic Cancer

Por Schirmer, Markus A., Lüske, Claudia M., Roppel, Sebastian, Schaudinn, Alexander, Zimmer, Christian, Pflüger, Ruben, Haubrock, Martin, Rapp, Jacobe, Güngör, Cenap, Bockhorn, Maximilian, Hackert, Thilo, Hank, Thomas, Strobel, Oliver, Werner, Jens, Izbicki, Jakob R., Johnsen, Steven A., Gaedcke, Jochen, Brockmöller, Jürgen, Ghadimi, B. Michael
Publicado no J Natl Cancer Inst (2016)