Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1

BACKGROUND: The organic cation transporter OCT1 (SLC22A1) mediates the uptake of vitamin B1, cationic drugs, and xenobiotics into hepatocytes. Nine percent of Caucasians lack or have very low OCT1 activity due to loss-of-function polymorphisms in OCT1 gene. Here we analyzed the global genetic variab...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Seitz, Tina, Stalmann, Robert, Dalila, Nawar, Chen, Jiayin, Pojar, Sherin, Dos Santos Pereira, Joao N., Krätzner, Ralph, Brockmöller, Jürgen, Tzvetkov, Mladen V.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4495841/
https://ncbi.nlm.nih.gov/pubmed/26157489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-015-0172-0
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