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Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine
BACKGROUND: Ranitidine (Zantac(®)) is a H(2)-receptor antagonist commonly used for the treatment of acid-related gastrointestinal diseases. Ranitidine was reported to be a substrate of the organic cation transporters OCT1 and OCT2. The hepatic transporter OCT1 is highly genetically variable. Twelve...
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| Publicado no: | PLoS One |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5728534/ https://ncbi.nlm.nih.gov/pubmed/29236753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189521 |
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