Effects of a Common Eight Base Pairs Duplication at the Exon 7-Intron 7 Junction on Splicing, Expression, and Function of OCT1

Organic cation transporter 1 (OCT1, SLC22A1) is localized in the sinusoidal membrane of human hepatocytes and mediates hepatic uptake of weakly basic or cationic drugs and endogenous compounds. Common amino acid substitutions in OCT1 were associated with altered pharmacokinetics and efficacy of drug...

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Xehetasun bibliografikoak
Argitaratua izan da:Front Pharmacol
Egile Nagusiak: Römer, Sarah, Meyer, Marleen J., Klein, Kathrin, Schneider, Lennart V., Matthaei, Johannes, Tzvetkova, Ana, Łapczuk-Romańska, Joanna, Gaedcke, Jochen, Droździk, Marek, Brockmöller, Jürgen, Nies, Anne T., Tzvetkov, Mladen V.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2021
Gaiak:
Pharmacology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137991/
https://ncbi.nlm.nih.gov/pubmed/34025422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.661480
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