RUNX-1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells

Patients with familial platelet disorder with a predisposition to myeloid malignancy (FPDMM) harbor germline monoallelic mutations in a key hematopoietic transcription factor, RUNX-1. Previous studies of FPDMM have focused on megakaryocyte (Mk) differentiation and platelet production and signaling....

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Gepubliceerd in:Blood
Hoofdauteurs: Estevez, Brian, Borst, Sara, Jarocha, Danuta, Sudunagunta, Varun, Gonzalez, Michael, Garifallou, James, Hakonarson, Hakon, Gao, Peng, Tan, Kai, Liu, Paul, Bagga, Sumedha, Holdreith, Nicholas, Tong, Wei, Speck, Nancy, French, Deborah L., Gadue, Paul, Poncz, Mortimer
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2021
Onderwerpen:
Platelets and Thrombopoiesis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8120143/
https://ncbi.nlm.nih.gov/pubmed/33569577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006389
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