Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Homodimeric class I cytokine receptors are assumed to exist as preformed dimers that are activated by ligand-induced conformational changes. We quantified the dimerization of three prototypic class I cytokine receptors in the plasma membrane of living cells by single-molecule fluorescence microscopy...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Science
Main Authors: Wilmes, Stephan, Hafer, Maximillian, Vuorio, Joni, Tucker, Julie A., Winkelmann, Hauke, Löchte, Sara, Stanly, Tess A., Prieto, Katiuska D. Pulgar, Poojari, Chetan, Sharma, Vivek, Richter, Christian P., Kurre, Rainer, Hubbard, Stevan R., Garcia, K. Christopher, Moraga, Ignacio, Vattulainen, Ilpo, Hitchcock, Ian S., Piehler, Jacob
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8117407/
https://ncbi.nlm.nih.gov/pubmed/32029621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw3242
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker