Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Homodimeric class I cytokine receptors are assumed to exist as preformed dimers that are activated by ligand-induced conformational changes. We quantified the dimerization of three prototypic class I cytokine receptors in the plasma membrane of living cells by single-molecule fluorescence microscopy...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Science
Egile Nagusiak: Wilmes, Stephan, Hafer, Maximillian, Vuorio, Joni, Tucker, Julie A., Winkelmann, Hauke, Löchte, Sara, Stanly, Tess A., Prieto, Katiuska D. Pulgar, Poojari, Chetan, Sharma, Vivek, Richter, Christian P., Kurre, Rainer, Hubbard, Stevan R., Garcia, K. Christopher, Moraga, Ignacio, Vattulainen, Ilpo, Hitchcock, Ian S., Piehler, Jacob
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8117407/
https://ncbi.nlm.nih.gov/pubmed/32029621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw3242
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak