Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Homodimeric class I cytokine receptors are assumed to exist as preformed dimers that are activated by ligand-induced conformational changes. We quantified the dimerization of three prototypic class I cytokine receptors in the plasma membrane of living cells by single-molecule fluorescence microscopy...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Science
Главные авторы: Wilmes, Stephan, Hafer, Maximillian, Vuorio, Joni, Tucker, Julie A., Winkelmann, Hauke, Löchte, Sara, Stanly, Tess A., Prieto, Katiuska D. Pulgar, Poojari, Chetan, Sharma, Vivek, Richter, Christian P., Kurre, Rainer, Hubbard, Stevan R., Garcia, K. Christopher, Moraga, Ignacio, Vattulainen, Ilpo, Hitchcock, Ian S., Piehler, Jacob
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8117407/
https://ncbi.nlm.nih.gov/pubmed/32029621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw3242
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы