Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Homodimeric class I cytokine receptors are assumed to exist as preformed dimers that are activated by ligand-induced conformational changes. We quantified the dimerization of three prototypic class I cytokine receptors in the plasma membrane of living cells by single-molecule fluorescence microscopy...

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Publicado no:Science
Main Authors: Wilmes, Stephan, Hafer, Maximillian, Vuorio, Joni, Tucker, Julie A., Winkelmann, Hauke, Löchte, Sara, Stanly, Tess A., Prieto, Katiuska D. Pulgar, Poojari, Chetan, Sharma, Vivek, Richter, Christian P., Kurre, Rainer, Hubbard, Stevan R., Garcia, K. Christopher, Moraga, Ignacio, Vattulainen, Ilpo, Hitchcock, Ian S., Piehler, Jacob
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8117407/
https://ncbi.nlm.nih.gov/pubmed/32029621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw3242
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