Receptor Density Is Key to the Alpha2/Beta Interferon Differential Activities

Por Moraga, Ignacio, Harari, Daniel, Schreiber, Gideon, Uzé, Gilles, Pellegrini, Sandra
Publicado em 2009

Multifarious Determinants of Cytokine Receptor Signaling Specificity

Por Moraga, Ignacio, Spangler, Jamie, Mendoza, Juan L., Garcia, K. Christopher
Publicado no Adv Immunol (2014)

Insights into Cytokine–Receptor Interactions from Cytokine Engineering

Por Spangler, Jamie B., Moraga, Ignacio, Mendoza, Juan L., Garcia, K. Christopher
Publicado no Annu Rev Immunol (2014)

Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling

Por You, Changjiang, Marquez-Lago, Tatiana T., Richter, Christian Paolo, Wilmes, Stephan, Moraga, Ignacio, Garcia, K. Christopher, Leier, André, Piehler, Jacob
Publicado no Sci Adv (2016)

Mechanistic and structural insight into the functional dichotomy between interleukin-2 and interleukin-15

Por Ring, Aaron M., Lin, Jian-Xin, Feng, Dan, Mitra, Suman, Rickert, Mathias, Bowman, Gregory R., Pande, Vijay S., Li, Peng, Moraga, Ignacio, Spolski, Rosanne, Özkan, Engin, Leonard, Warren J., Garcia, K. Christopher
Publicado em 2012

Structural linkage between ligand discrimination and receptor activation by type I interferons

Por Thomas, Christoph, Moraga, Ignacio, Levin, Doron, Krutzik, Peter O., Podoplelova, Yulia, Trejo, Angelica, Lee, Choongho, Yarden, Ganit, Vleck, Susan E., Glenn, Jeffrey S., Nolan, Garry P., Piehler, Jacob, Schreiber, Gideon, Garcia, K. Christopher
Publicado em 2011

Exploiting a natural conformational switch to engineer an Interleukin-2 superkine

Por Levin, Aron M., Bates, Darren L., Ring, Aaron M., Krieg, Carsten, Lin, Jack T., Su, Leon, Moraga, Ignacio L., Raeber, Miro E., Bowman, Gregory R., Novick, Paul, Pande, Vijay S., Fathman, C. Garrison, Boyman, Onur, Garcia, K. Christopher
Publicado em 2012

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines

Por Junttila, Ilkka S., Creusot, Remi J., Moraga, Ignacio, Bates, Darren L., Wong, Michael T., Alonso, Michael N., Suhoski, Megan M., Lupardus, Patrick, Meier-Schellersheim, Martin, Engleman, Edgar G., Utz, Paul J., Fathman, C. Garrison, Paul, William E., Garcia, K. Christopher
Publicado em 2012

Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands

Por Moraga, Ignacio, Wernig, Gerlinde, Wilmes, Stephan, Gryshkova, Vitalina, Richter, Christian Paolo, Hong, Wan-Jen, Sinha, Rahul, Guo, Feng, Fabionar, Hyna, Wehrman, Tom S., Krutzik, Peter, Demharter, Samuel, Plo, Isabelle, Weissman, Irving L., Minary, Peter, Majeti, Ravindra, Constantinescu, Stefan N., Piehler, Jacob, Garcia, K. Christopher
Publicado no Cell (2015)

Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation

Por Kim, Ah Ram, Ulirsch, Jacob C., Wilmes, Stephan, Unal, Ekrem, Moraga, Ignacio, Karakukcu, Musa, Yuan, Daniel, Kazerounian, Shideh, Abdulhay, Nour J., King, David S., Gupta, Namrata, Gabriel, Stacey B., Lander, Eric S., Patiroglu, Turkan, Ozcan, Alper, Ozdemir, Mehmet Akif, Garcia, K. Christopher, Piehler, Jacob, Gazda, Hanna T., Klein, Daryl E., Sankaran, Vijay G.
Publicado no Cell (2017)