Structural linkage between ligand discrimination and receptor activation by type I interferons

Type I Interferons (IFNs) are important cytokines for innate immunity against viruses and cancer. Sixteen human IFN variants signal through the same cell surface receptors, IFNAR1 and IFNAR2, yet they can evoke markedly different physiological effects. The crystal structures of two human type I IFN...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Thomas, Christoph, Moraga, Ignacio, Levin, Doron, Krutzik, Peter O., Podoplelova, Yulia, Trejo, Angelica, Lee, Choongho, Yarden, Ganit, Vleck, Susan E., Glenn, Jeffrey S., Nolan, Garry P., Piehler, Jacob, Schreiber, Gideon, Garcia, K. Christopher
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166218/
https://ncbi.nlm.nih.gov/pubmed/21854986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.06.048
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