Structural linkage between ligand discrimination and receptor activation by type I interferons

Type I Interferons (IFNs) are important cytokines for innate immunity against viruses and cancer. Sixteen human IFN variants signal through the same cell surface receptors, IFNAR1 and IFNAR2, yet they can evoke markedly different physiological effects. The crystal structures of two human type I IFN...

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Bibliografische gegevens
Hoofdauteurs: Thomas, Christoph, Moraga, Ignacio, Levin, Doron, Krutzik, Peter O., Podoplelova, Yulia, Trejo, Angelica, Lee, Choongho, Yarden, Ganit, Vleck, Susan E., Glenn, Jeffrey S., Nolan, Garry P., Piehler, Jacob, Schreiber, Gideon, Garcia, K. Christopher
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166218/
https://ncbi.nlm.nih.gov/pubmed/21854986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.06.048
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