Structural linkage between ligand discrimination and receptor activation by type I interferons

Type I Interferons (IFNs) are important cytokines for innate immunity against viruses and cancer. Sixteen human IFN variants signal through the same cell surface receptors, IFNAR1 and IFNAR2, yet they can evoke markedly different physiological effects. The crystal structures of two human type I IFN...

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Detalhes bibliográficos
Main Authors: Thomas, Christoph, Moraga, Ignacio, Levin, Doron, Krutzik, Peter O., Podoplelova, Yulia, Trejo, Angelica, Lee, Choongho, Yarden, Ganit, Vleck, Susan E., Glenn, Jeffrey S., Nolan, Garry P., Piehler, Jacob, Schreiber, Gideon, Garcia, K. Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166218/
https://ncbi.nlm.nih.gov/pubmed/21854986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.06.048
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