Mechanistic and structural insight into the functional dichotomy between interleukin-2 and interleukin-15

Interleukin-15 (IL-15) and IL-2 possess distinct immunological functions despite both signaling through IL-2Rβ and the common cytokine receptor γ-chain, γ(c), We find that in the IL-15—IL-15Rα—IL-2Rβ—γ(c) quaternary complex structure, IL-15 heterodimerizes IL-2Rβ and γ(c) identically to the IL-2—IL-...

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Detalhes bibliográficos
Main Authors: Ring, Aaron M., Lin, Jian-Xin, Feng, Dan, Mitra, Suman, Rickert, Mathias, Bowman, Gregory R., Pande, Vijay S., Li, Peng, Moraga, Ignacio, Spolski, Rosanne, Özkan, Engin, Leonard, Warren J., Garcia, K. Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501574/
https://ncbi.nlm.nih.gov/pubmed/23104097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2449
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