Interleukin-2 Activity can be Fine-Tuned with Engineered Receptor Signaling Clamps

Interleukin-2 (IL-2) regulates lymphocyte function by signaling through heterodimerization of the IL-2Rβ and γ(c) receptor subunits. IL-2 is of considerable therapeutic interest, but harnessing its actions in a controllable manner remains a challenge. Previously, we have engineered an IL-2 “superkin...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Mitra, Suman, Ring, Aaron M., Amarnath, Shoba, Spangler, Jamie B., Li, Peng, Ju, Wei, Fischer, Suzanne, Oh, Jangsuk, Spolski, Rosanne, Weiskopf, Kipp, Kohrt, Holbrook, Foley, Jason E., Rajagopalan, Sumati, Long, Eric O., Fowler, Daniel H., Waldmann, Thomas A., Garcia, K. Christopher, Leonard, Warren J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560365/
https://ncbi.nlm.nih.gov/pubmed/25992859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.04.018
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