Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion

Metabolic fuels regulate insulin secretion by generating second messengers that drive insulin granule exocytosis, but the biochemical pathways involved are incompletely understood. Here we demonstrate that stimulation of rat insulinoma cells or primary rat islets with glucose or glutamine + 2-aminob...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Metab
Auteurs principaux: Zhang, Guo-Fang, Jensen, Mette V., Gray, Sarah M., El, Kimberley, Wang, You, Lu, Danhong, Becker, Thomas C., Campbell, Jonathan E., Newgard, Christopher B.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115731/
https://ncbi.nlm.nih.gov/pubmed/33321098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.11.020
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