Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion

Metabolic fuels regulate insulin secretion by generating second messengers that drive insulin granule exocytosis, but the biochemical pathways involved are incompletely understood. Here we demonstrate that stimulation of rat insulinoma cells or primary rat islets with glucose or glutamine + 2-aminob...

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Foilsithe in:Cell Metab
Main Authors: Zhang, Guo-Fang, Jensen, Mette V., Gray, Sarah M., El, Kimberley, Wang, You, Lu, Danhong, Becker, Thomas C., Campbell, Jonathan E., Newgard, Christopher B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115731/
https://ncbi.nlm.nih.gov/pubmed/33321098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.11.020
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