Control of Voltage-gated Potassium Channel Kv2.2 Expression by Pyruvate-Isocitrate Cycling Regulates Glucose-stimulated Insulin Secretion

Recent studies have shown that the pyruvate-isocitrate cycling pathway, involving the mitochondrial citrate/isocitrate carrier and the cytosolic NADP-dependent isocitrate dehydrogenase (ICDc), is involved in control of glucose-stimulated insulin secretion (GSIS). Here we demonstrate that pyruvate-is...

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Detalhes bibliográficos
Main Authors: Jensen, Mette V., Haldeman, Jonathan M., Zhang, Hengtao, Lu, Danhong, Huising, Mark O., Vale, Wylie W., Hohmeier, Hans E., Rosenberg, Paul, Newgard, Christopher B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743485/
https://ncbi.nlm.nih.gov/pubmed/23788641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.491654
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