A carregar...
C(sp(3))–H methylation enabled by peroxide photosensitization and Ni-mediated radical coupling
The “magic methyl” effect describes the change in potency, selectivity, and/or metabolic stability of a drug candidate associated with addition of a single methyl group. Here, we report a synthetic method that enables direct methylation of C(sp(3))–H bonds in diverse drug-like molecules and pharmace...
Na minha lista:
| Publicado no: | Science |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8110093/ https://ncbi.nlm.nih.gov/pubmed/33888639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abh2623 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|