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C(sp(3))–H methylation enabled by peroxide photosensitization and Ni-mediated radical coupling
The “magic methyl” effect describes the change in potency, selectivity, and/or metabolic stability of a drug candidate associated with addition of a single methyl group. Here, we report a synthetic method that enables direct methylation of C(sp(3))–H bonds in diverse drug-like molecules and pharmace...
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| Foilsithe in: | Science |
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| Main Authors: | , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2021
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8110093/ https://ncbi.nlm.nih.gov/pubmed/33888639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abh2623 |
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