Schlafen 5 as a Novel Therapeutic Target in Pancreatic Ductal Adenocarcinoma

We provide evidence that a member of the human Schlafen (SLFN) family of proteins, SLFN5, is overexpressed in human pancreatic ductal adenocarcinoma (PDAC). Targeted deletion of SLFN5 results in decreased PDAC cell proliferation and suppresses PDAC tumorigenesis in in vivo PDAC models. Importantly,...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Fischietti, Mariafausta, Eckerdt, Frank, Blyth, Gavin T., Arslan, Ahmet D., Mati, William M., Oku, Chidera V., Perez, Ricardo E., Lee-Chang, Catalina, Kosciuczuk, Ewa M., Saleiro, Diana, Beauchamp, Elspeth M., Lesniak, Maciej S., Verzella, Daniela, Sun, Leyu, Fish, Eleanor N., Yang, Guang-Yu, Qiang, Wenan, Platanias, Leonidas C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106654/
https://ncbi.nlm.nih.gov/pubmed/33846574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01761-1
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