Schlafen 5 as a Novel Therapeutic Target in Pancreatic Ductal Adenocarcinoma

We provide evidence that a member of the human Schlafen (SLFN) family of proteins, SLFN5, is overexpressed in human pancreatic ductal adenocarcinoma (PDAC). Targeted deletion of SLFN5 results in decreased PDAC cell proliferation and suppresses PDAC tumorigenesis in in vivo PDAC models. Importantly,...

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Bibliografiske detaljer
Udgivet i:Oncogene
Main Authors: Fischietti, Mariafausta, Eckerdt, Frank, Blyth, Gavin T., Arslan, Ahmet D., Mati, William M., Oku, Chidera V., Perez, Ricardo E., Lee-Chang, Catalina, Kosciuczuk, Ewa M., Saleiro, Diana, Beauchamp, Elspeth M., Lesniak, Maciej S., Verzella, Daniela, Sun, Leyu, Fish, Eleanor N., Yang, Guang-Yu, Qiang, Wenan, Platanias, Leonidas C.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106654/
https://ncbi.nlm.nih.gov/pubmed/33846574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01761-1
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