Human SLFN5 is a Transcriptional Co-repressor of STAT1-Mediated Interferon Responses and Promotes the Malignant Phenotype in Glioblastoma

We provide evidence that the IFN-regulated member of the Schlafen (SLFN) family of proteins, SLFN5, promotes the malignant phenotype in glioblastoma multiforme (GBM). Our studies indicate that SLFN5 expression promotes motility and invasiveness of GBM cells, and that high levels of SLFN5 expression...

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Pubblicato in:Oncogene
Autori principali: Arslan, Ahmet Dirim, Sassano, Antonella, Saleiro, Diana, Lisowski, Pawel, Kosciuczuk, Ewa M., Fischietti, Mariafausta, Eckerdt, Frank, Fish, Eleanor N., Platanias, Leonidas C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821504/
https://ncbi.nlm.nih.gov/pubmed/28671669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.205
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