Merestinib blocks Mnk kinase activity in acute myeloid leukemia progenitors and exhibits antileukemic effects in vitro and in vivo

Mitogen-activated protein kinase interacting protein kinases (Mnks) play important roles in the development and progression of acute myeloid leukemia (AML) by regulating eukaryotic translation initiation factor 4E (eIF4E) activation. Inhibiting Mnk1/2-induced phosphorylation of eIF4E may represent a...

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Publicado en:Blood
Main Authors: Kosciuczuk, Ewa M., Saleiro, Diana, Kroczynska, Barbara, Beauchamp, Elspeth M., Eckerdt, Frank, Blyth, Gavin T., Abedin, Sameem M., Giles, Francis J., Altman, Jessica K., Platanias, Leonidas C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2016
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957163/
https://ncbi.nlm.nih.gov/pubmed/27307295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-02-698704
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