Potent Antineoplastic Effects of Combined PI3Kα-MNK Inhibition in Medulloblastoma

Medulloblastoma is a highly malignant pediatric brain tumor associated with poor outcome. Developing treatments that target the cancer stem cell (CSC) population in medulloblastoma are important to prevent tumor relapse and induce long-lasting clinical responses. We utilized medulloblastoma neurosph...

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Bibliographic Details
Published in:Mol Cancer Res
Main Authors: Eckerdt, Frank, Bell, Jonathan B., Beauchamp, Elspeth M., Clymer, Jessica, Blyth, Gavin T., Kosciuczuk, Ewa M., Ma, Quanhong, Chen, David Z., Horbinski, Craig, Goldman, Stewart, Munshi, Hidayatullah G., Hashizume, Rintaro, Platanias, Leonidas C.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548590/
https://ncbi.nlm.nih.gov/pubmed/30842251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-1193
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