Potent Antineoplastic Effects of Combined PI3Kα-MNK Inhibition in Medulloblastoma

Medulloblastoma is a highly malignant pediatric brain tumor associated with poor outcome. Developing treatments that target the cancer stem cell (CSC) population in medulloblastoma are important to prevent tumor relapse and induce long-lasting clinical responses. We utilized medulloblastoma neurosph...

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發表在:Mol Cancer Res
Main Authors: Eckerdt, Frank, Bell, Jonathan B., Beauchamp, Elspeth M., Clymer, Jessica, Blyth, Gavin T., Kosciuczuk, Ewa M., Ma, Quanhong, Chen, David Z., Horbinski, Craig, Goldman, Stewart, Munshi, Hidayatullah G., Hashizume, Rintaro, Platanias, Leonidas C.
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548590/
https://ncbi.nlm.nih.gov/pubmed/30842251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-1193
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