Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells

The mTOR pathway controls mRNA translation of mitogenic proteins and is a central regulator of metabolism in malignant cells. Development of malignant cell resistance is a limiting factor to the effects of mTOR inhibitors, but the mechanisms accounting for such resistance are not well understood. We...

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Publicat a:Oncotarget
Autors principals: Eckerdt, Frank, Beauchamp, Elspeth, Bell, Jonathan, Iqbal, Asneha, Su, Bing, Fukunaga, Rikiro, Lulla, Rishi R., Goldman, Stewart, Platanias, Leonidas C.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226695/
https://ncbi.nlm.nih.gov/pubmed/25193863
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