Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway

Chikungunya virus (CHIKV), the causative agent of a major epidemic spanning five continents, is a positive stranded mRNA virus that replicates using the cell’s cap-dependent translation machinery. Despite viral infection inhibiting mTOR, a metabolic sensor controls cap-dependent translation, viral p...

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Vydáno v:PLoS Pathog
Hlavní autoři: Joubert, Pierre-Emmanuel, Stapleford, Kenneth, Guivel-Benhassine, Florence, Vignuzzi, Marco, Schwartz, Olivier, Albert, Matthew L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552638/
https://ncbi.nlm.nih.gov/pubmed/26317997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005091
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