Merestinib blocks Mnk kinase activity in acute myeloid leukemia progenitors and exhibits antileukemic effects in vitro and in vivo

Mitogen-activated protein kinase interacting protein kinases (Mnks) play important roles in the development and progression of acute myeloid leukemia (AML) by regulating eukaryotic translation initiation factor 4E (eIF4E) activation. Inhibiting Mnk1/2-induced phosphorylation of eIF4E may represent a...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Blood
Autors principals: Kosciuczuk, Ewa M., Saleiro, Diana, Kroczynska, Barbara, Beauchamp, Elspeth M., Eckerdt, Frank, Blyth, Gavin T., Abedin, Sameem M., Giles, Francis J., Altman, Jessica K., Platanias, Leonidas C.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2016
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957163/
https://ncbi.nlm.nih.gov/pubmed/27307295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-02-698704
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars