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Antileukemic effects of AMPK activators on BCR-ABL–expressing cells
The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in growth and survival of BCR-ABL transformed cells. AMPK kinase is a metabolic sensor that exhibits suppressive effects on the mTOR pathway and negatively regulates mTOR activity. We report that AMPK activators, such a...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society of Hematology
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3236122/ https://ncbi.nlm.nih.gov/pubmed/22021366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-332783 |
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