Antileukemic effects of AMPK activators on BCR-ABL–expressing cells

The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in growth and survival of BCR-ABL transformed cells. AMPK kinase is a metabolic sensor that exhibits suppressive effects on the mTOR pathway and negatively regulates mTOR activity. We report that AMPK activators, such a...

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Bibliographic Details
Main Authors: Vakana, Eliza, Altman, Jessica K., Glaser, Heather, Donato, Nicholas J., Platanias, Leonidas C.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236122/
https://ncbi.nlm.nih.gov/pubmed/22021366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-332783
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