Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors

Mnk kinases regulate the phosphorylation and activation of the eukaryotic initiation factor 4E (eIF4E), a protein that plays key roles in the initiation of messenger RNA translation and whose activity is critical for various cellular functions. eIF4E is deregulated in acute myeloid leukemia (AML), a...

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Main Authors: Altman, Jessica K., Szilard, Amy, Konicek, Bruce W., Iversen, Philip W., Kroczynska, Barbara, Glaser, Heather, Sassano, Antonella, Vakana, Eliza, Graff, Jeremy R., Platanias, Leonidas C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2013
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643766/
https://ncbi.nlm.nih.gov/pubmed/23509154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-01-477216
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