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Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins
ETS family transcription factors of ERG and FLI1 play a key role in oncogenesis of prostate cancer and Ewing sarcoma by binding regulatory DNA sites and interfering with function of other factors. Mithramycin (MTM) is an anti-cancer, DNA binding natural product that functions as a potent antagonist...
Gardado en:
| Publicado en: | Structure |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8106648/ https://ncbi.nlm.nih.gov/pubmed/33275876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.11.012 |
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