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Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins

ETS family transcription factors of ERG and FLI1 play a key role in oncogenesis of prostate cancer and Ewing sarcoma by binding regulatory DNA sites and interfering with function of other factors. Mithramycin (MTM) is an anti-cancer, DNA binding natural product that functions as a potent antagonist...

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Publicat a:Structure
Autors principals: Hou, Caixia, Mandal, Abhisek, Rohr, Jürgen, Tsodikov, Oleg V.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106648/
https://ncbi.nlm.nih.gov/pubmed/33275876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.11.012
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