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How mithramycin stereochemistry dictates its structure and DNA binding function
An aureolic acid natural product mithramycin (MTM) has been known for its potent antineoplastic properties. MTM inhibits cell growth by binding in the minor groove of double-stranded DNA as a dimer, in which the two molecules of MTM are coordinated to each other through a divalent metal ion. A cryst...
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| Publicat a: | Medchemcomm |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Royal Society of Chemistry
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6533888/ https://ncbi.nlm.nih.gov/pubmed/31191864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00100j |
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