Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1

Transcription factors have been considered undruggable, but this paradigm has been recently challenged. DNA binding natural product mithramycin (MTM) is a potent antagonist of oncogenic transcription factor EWS–FLI1. Structural details of MTM recognition of DNA, including the FLI1 binding sequence G...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Hou, Caixia, Weidenbach, Stevi, Cano, Kristin E., Wang, Zhonghua, Mitra, Prithiba, Ivanov, Dmitri N., Rohr, Jürgen, Tsodikov, Oleg V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Structural Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063001/
https://ncbi.nlm.nih.gov/pubmed/27587584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw761
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