Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1

Transcription factors have been considered undruggable, but this paradigm has been recently challenged. DNA binding natural product mithramycin (MTM) is a potent antagonist of oncogenic transcription factor EWS–FLI1. Structural details of MTM recognition of DNA, including the FLI1 binding sequence G...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Hou, Caixia, Weidenbach, Stevi, Cano, Kristin E., Wang, Zhonghua, Mitra, Prithiba, Ivanov, Dmitri N., Rohr, Jürgen, Tsodikov, Oleg V.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063001/
https://ncbi.nlm.nih.gov/pubmed/27587584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw761
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