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Dimerization and DNA recognition rules of mithramycin and its analogues
The antineoplastic and antibiotic natural product mithramycin (MTM) is used against cancer-related hypercalcemia and, experimentally, against Ewing sarcoma and lung cancers. MTM exerts its cytotoxic effect by binding DNA as a divalent metal ion (Me(2+))-coordinated dimer and disrupting the function...
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| Publicado no: | J Inorg Biochem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4874495/ https://ncbi.nlm.nih.gov/pubmed/26760230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2015.12.011 |
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