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Dimerization and DNA recognition rules of mithramycin and its analogues
The antineoplastic and antibiotic natural product mithramycin (MTM) is used against cancer-related hypercalcemia and, experimentally, against Ewing sarcoma and lung cancers. MTM exerts its cytotoxic effect by binding DNA as a divalent metal ion (Me(2+))-coordinated dimer and disrupting the function...
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| Опубликовано в: : | J Inorg Biochem |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4874495/ https://ncbi.nlm.nih.gov/pubmed/26760230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2015.12.011 |
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