CD8 Lymphocyte Depletion Enhances the Latency Reversal Activity of the SMAC Mimetic AZD5582 in ART-Suppressed Simian Immunodeficiency Virus-Infected Rhesus Macaques

Inducing latency reversal to reveal infected cells to the host immune system represents a potential strategy to cure human immunodeficiency virus (HIV) infection. In separate studies, we have shown previously that CD8(+) T cells may contribute to the maintenance of viral latency and have identified...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Mavigner, Maud, Liao, Laura E., Brooks, Alyssa D., Ke, Ruian, Mattingly, Cameron, Schoof, Nils, McBrien, Julia, Carnathan, Diane, Liang, Shan, Vanderford, Thomas H., Paiardini, Mirko, Kulpa, Deanna, Lifson, Jeffrey D., Dunham, Richard M., Easley, Kirk A., Margolis, David M., Perelson, Alan S., Silvestri, Guido, Chahroudi, Ann
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2021
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103677/
https://ncbi.nlm.nih.gov/pubmed/33568515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01429-20
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