Short-Term Pegylated Interferon α2a Treatment Does Not Significantly Reduce the Viral Reservoir of Simian Immunodeficiency Virus-Infected, Antiretroviral Therapy-Treated Rhesus Macaques

The major obstacle to human immunodeficiency type 1 (HIV-1) eradication is a reservoir of latently infected cells that persists despite long-term antiretroviral therapy (ART) and causes rapid viral rebound if treatment is interrupted. Type I interferons are immunomodulatory cytokines that induce ant...

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Bibliographic Details
Published in:J Virol
Main Authors: Palesch, David, Bosinger, Steven E., Mavigner, Maud, Billingsley, James M., Mattingly, Cameron, Carnathan, Diane G., Paiardini, Mirko, Chahroudi, Ann, Vanderford, Thomas H., Silvestri, Guido
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026735/
https://ncbi.nlm.nih.gov/pubmed/29720521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00279-18
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