Antibody-Mediated CD4 Depletion Induces Homeostatic CD4(+) T Cell Proliferation without Detectable Virus Reactivation in Antiretroviral Therapy-Treated Simian Immunodeficiency Virus-Infected Macaques

A major barrier to human immunodeficiency virus (HIV) eradication is the long-term persistence of latently infected CD4(+) T cells harboring integrated replication-competent virus. It has been proposed that the homeostatic proliferation of these cells drives long-term reservoir persistence in the ab...

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Vydáno v:J Virol
Hlavní autoři: Kumar, Nitasha A., McBrien, Julia B., Carnathan, Diane G., Mavigner, Maud, Mattingly, Cameron, White, Erick R., Viviano, Federico, Bosinger, Steve E., Chahroudi, Ann, Silvestri, Guido, Paiardini, Mirko, Vanderford, Thomas H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206490/
https://ncbi.nlm.nih.gov/pubmed/30185596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01235-18
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