CD8 Lymphocyte Depletion Enhances the Latency Reversal Activity of the SMAC Mimetic AZD5582 in ART-Suppressed Simian Immunodeficiency Virus-Infected Rhesus Macaques

Inducing latency reversal to reveal infected cells to the host immune system represents a potential strategy to cure human immunodeficiency virus (HIV) infection. In separate studies, we have shown previously that CD8(+) T cells may contribute to the maintenance of viral latency and have identified...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Mavigner, Maud, Liao, Laura E., Brooks, Alyssa D., Ke, Ruian, Mattingly, Cameron, Schoof, Nils, McBrien, Julia, Carnathan, Diane, Liang, Shan, Vanderford, Thomas H., Paiardini, Mirko, Kulpa, Deanna, Lifson, Jeffrey D., Dunham, Richard M., Easley, Kirk A., Margolis, David M., Perelson, Alan S., Silvestri, Guido, Chahroudi, Ann
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103677/
https://ncbi.nlm.nih.gov/pubmed/33568515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01429-20
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