CD8 Lymphocyte Depletion Enhances the Latency Reversal Activity of the SMAC Mimetic AZD5582 in ART-Suppressed Simian Immunodeficiency Virus-Infected Rhesus Macaques

Inducing latency reversal to reveal infected cells to the host immune system represents a potential strategy to cure human immunodeficiency virus (HIV) infection. In separate studies, we have shown previously that CD8(+) T cells may contribute to the maintenance of viral latency and have identified...

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Veröffentlicht in:J Virol
Hauptverfasser: Mavigner, Maud, Liao, Laura E., Brooks, Alyssa D., Ke, Ruian, Mattingly, Cameron, Schoof, Nils, McBrien, Julia, Carnathan, Diane, Liang, Shan, Vanderford, Thomas H., Paiardini, Mirko, Kulpa, Deanna, Lifson, Jeffrey D., Dunham, Richard M., Easley, Kirk A., Margolis, David M., Perelson, Alan S., Silvestri, Guido, Chahroudi, Ann
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2021
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103677/
https://ncbi.nlm.nih.gov/pubmed/33568515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01429-20
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