Combination of CD8β Depletion and Interleukin-15 Superagonist N-803 Induces Virus Reactivation in Simian-Human Immunodeficiency Virus-Infected, Long-Term ART-Treated Rhesus Macaques

The “shock and kill” strategy predicates that virus reactivation in latently infected cells is required to eliminate the human immunodeficiency virus (HIV) reservoir. In a recent study, we showed robust and persistent induction of plasma viremia in antiretroviral therapy (ART)-treated simian immunod...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: McBrien, Julia B., Wong, Andrew K. H., White, Erick, Carnathan, Diane G., Lee, John H., Safrit, Jeffrey T., Vanderford, Thomas H., Paiardini, Mirko, Chahroudi, Ann, Silvestri, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495383/
https://ncbi.nlm.nih.gov/pubmed/32669328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00755-20
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