In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8(+) T cell fate decisions

How early events in effector T cell (T(EFF)) subsets tune memory T cell (T(MEM)) responses remains incompletely understood. Here, we systematically investigated metabolic factors in fate determination of T(EFF) and T(MEM) cells using in vivo pooled CRISPR screening, focusing on negative regulators o...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Huang, Hongling, Zhou, Peipei, Wei, Jun, Long, Lingyun, Shi, Hao, Dhungana, Yogesh, Chapman, Nicole M., Fu, Guotong, Saravia, Jordy, Raynor, Jana L., Liu, Shaofeng, Palacios, Gustavo, Wang, Yong-Dong, Qian, Chenxi, Yu, Jiyang, Chi, Hongbo
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8101447/
https://ncbi.nlm.nih.gov/pubmed/33636132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.02.021
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