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Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions

Invariant natural killer T (iNKT) cells acquire effector functions during development by mechanisms that remain poorly understood. Here, we show that the Hippo kinases Mst1 and Mst2 act as molecular rheostats for the terminal maturation and effector differentiation programs of iNKT cells. Loss of Ms...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Raynor, Jana L., Liu, Chaohong, Dhungana, Yogesh, Guy, Cliff, Chapman, Nicole M., Shi, Hao, Neale, Geoffrey, Sesaki, Hiromi, Chi, Hongbo
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7971129/
https://ncbi.nlm.nih.gov/pubmed/32289155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191157
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